A substrate radical intermediate in catalysis by the antibiotic resistance protein Cfr
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منابع مشابه
A Substrate Radical Intermediate in Catalysis by the Antibiotic Resistance Protein Cfr
Cfr-dependent methylation of C8 of A2503 in 23S ribosomal RNA confers bacterial resistance to an array of clinically important antibiotics that target the large subunit of the ribosome, including the synthetic oxazolidinone antibiotic linezolid. The key element of the proposed mechanism for Cfr, a radical S-adenosylmethionine enzyme, is the addition of a methylene radical, generated by hydrogen...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2013
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.1251